Genomic approaches for monitoring transmission dynamics of malaria: A case for malaria molecular surveillance in Sub–Saharan Africa
نویسندگان
چکیده
Transmission dynamics is an important indicator for malaria control and elimination. As we move closer to eliminating in Sub-Saharan Africa (sSA), transmission indices with higher resolution (genomic approaches) will complement our current measurements of transmission. Most the present programmatic knowledge patterns are derived from assessments epidemiologic clinical data, such as case counts, parasitological estimates parasite prevalence, Entomological Inoculation Rates (EIR). However, eliminate endemic areas, need track changes population how they impact This made possible through evolving field genomics genetics, well development tools more in-depth studies on diversity parasites complexity infections, among other topics. If elimination be achieved globally, country-specific activities should supported by genomic data regularly collected blood samples diagnosis, surveillance possibly interventions. presents a unique opportunity spread shed additional light intervention efficacy. In this review, various genetic techniques highlighted along their significance enhanced understanding distinct topological settings throughout Africa. The importance these methods limitations guide strategies, explored.
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ژورنال
عنوان ژورنال: Frontiers in epidemiology
سال: 2022
ISSN: ['2674-1199']
DOI: https://doi.org/10.3389/fepid.2022.939291